1

Set 5: Words in Context (Intermediate)

Explanation

Answer: B

PASSAGE

The researchers found that the medication was effective in treating the symptoms, but its impact on the underlying disease was ______, showing little to no significant change.

Which choice completes the text with the most logical and precise word or phrase?

A. profound
B. negligible✓ Correct
C. immediate
D. harmful

Detailed Explanation

If there was 'little to no significant change', the impact was tiny. 'Negligible' means so small or unimportant as to be not worth considering.

Key Evidence:

• "showing little to no significant change"

• "effective ... but"

Why others are wrong: A (Profound means very great.), C (Immediate refers to time.), D (Harmful means damaging, but 'little change' implies ineffectiveness, not harm.).