Choice D is the correct answer. To expand a binomial squared $(a - b)^2$, use the formula $a^2 - 2ab + b^2$.

1. Here $a = 2x$ and $b = 5$.
2. $a^2 = (2x)^2 = 4x^2$.
3. $-2ab = -2(2x)(5) = -20x$.
4. $b^2 = 5^2 = 25$.

Combine them: $4x^2 - 20x + 25$.

Choice A is incorrect because it misses the middle term. This is a very common mistake. Choice B is incorrect because it also misses the middle term. Choice C is incorrect because the middle term is calculated as $-2(x)(5)$ instead of $-2(2x)(5)$.